Another study showed an increase in PKC-δ isozyme, but not of PKC-α or PKC-ε, in volume-overload-induced left ventricular hypertrophy; however, PKC-α was found, along with PKC-δ, to have increased enzyme activity and protein expression in right ventricular hypertrophy [112]. The gene discussed is PRKCD; the disease is Right ventricular hypertrophy.