After aortic constriction-induced cardiac hypertrophy, CaMKII δ and γ levels are increased, although the highest degree of autophosphorylation occurs in CaMKII δ [92], implying that inhibition of the δ isoform would have a greater effect in reducing cardiac hypertrophy without causing extensive disruption to normal CaMKII function. The gene discussed is CAMK2G; the disease is cardiac hypertrophy.