The results demonstrated that the targeted therapy using Avastin along with PDT improved tumor responsiveness by inhibiting not only VEGF expression but also other angiogenic proteins such as angiogenin, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), interleukin-6 (IL-6) and interleukin-8 (IL-8) [77]. This evidence concerns the gene IL6 and neoplasm.