SOAT1 and rheumatoid arthritis: However, since activation of the JAK/STAT pathway has also been recognized to be highly involved in perpetuating the progression of adult RA pathology, the construction of small molecule inhibitors (SMIs) that specifically block activation of JAK/STAT has been the focus of several in vitro studies using tumor cells [28,29,30,31,32,33,34,35] and as a possible therapy for kidney transplant rejection [36].