In the large Atherosclerosis Risk in Communities (ARIC) study, conducted in 608 men and women with incident CHD and 740 controls, and followed for at least six years, after multivariable adjustments, Lp-PLA2 was not associated with an increased risk for CHD, except in subjects with LDL cholesterol below the median of 130 mg/dL [35]. The gene discussed is PLA2G7; the disease is atherosclerosis.