Since inflammation plays a major role at all stages of atherogenesis, from endothelial dysfunction to plaque development and ultimately to plaque rupture, Lp-PLA2 may contribute to atherosclerosis by generation of various proinflammatory lipid mediators, including Lyso-PC, ox-FA, and arachidonic acid [7]. Here, PLA2G7 is linked to endothelial dysfunction.