PLA2G7 and acute coronary syndrome: To date, the vast majority of prospective studies analyzing the association between Lp-PLA2  and subsequent cardiovascular (CV) events demonstrated a strong, positive, statistically significant and independent association between increased Lp-PLA2 mass or elevated activity and future CV risk, including a wide variety of clinical settings, i.e., apparently healthy men and women, elderly subjects, patients with acute coronary syndrome (ACS), and with stable CHD (Figure 2).