In ARIC, individuals with high Lp-PLA2 and high CRP exhibited a threefold increased risk for CHD (HR 2.95; 95%CI 1.47–5.94), whereas in our study the combination of elevated Lp-PLA2 and elevated CRP resulted in a HR of 1.93 (95%CI 1.09–3.40) compared with both markers not being increased in the fully adjusted model. This evidence concerns the gene CRP and coronary artery disorder.