The potential association between Lp-PLA2 and cardiovascular outcome was first demonstrated in WOSCOPS (West of Scotland Coronary Prevention Study), where 580 hypercholesterolemic middle-aged, initial healthy men, who developed a CHD event over a 4.9-year follow-up (FU), served as cases and were compared to 1,160 matched event-free controls [32]. Here, PLA2G7 is linked to coronary artery disorder.