Within the LURIC (Ludwigshafen Risk and Cardiovascular Health) study Lp-PLA2 activity predicted risk for cardiac and total mortality over 5.5 years in 2513 patients with angiographically confirmed CHD and 719 without, and added prognostic information in patients with low and medium CRP concentration with regard to 5-year cardiac mortality independently of established risk factors [50]. The gene discussed is CRP; the disease is coronary artery disorder.