TGFB1 and neoplasm: A peptide representing the Hep-I sequence induced promyelocytic leukemia cell differentiation and apoptosis [229], while 3TSR inhibited proliferation and induced apoptosis of B16F10 tumor cells in a TGF-β-dependent manner [114] in vitro and reduced tumor growth in orthotopic pancreatic xenografts [230,231] and in a model of polyoma middle T transgenic mice [232].