Accordingly, topical delivery of p53 DNA to the lung increased TSP-1 expression, reduced microvessel density and limited lung tumor burden, prolonging the survival of tumor-bearing mice [217]; viii) c-Myc-regulated cluster miRNA-17-92, over-expressed in many human cancers, inhibited TSP-1 expression in cancer cells and in ECs. Here, THBS1 is linked to cancer.