THBS1 and neoplasm: iv) expression of 3TSR or of the second type I repeats containing the TGF-β-activating sequences significantly inhibited in vivo tumor angiogenesis and growth in nude mice [212]; v) expression of TSP-1-derived 4N1K peptide-containing proteins in renal cell carcinoma tissues was associated with a decrease in tumor growth and angiogenesis [213]; vi) transfection of a TSP-1 complementary cDNA antisense into glioblastoma cells lines significantly reduced TSP-1 production and cell motility [214]; vii) p53 inactivation lowered TSP-1 production [215,216].