THBS1 and malignant colon neoplasm: Similarly, TSP-1 is induced in colon cancer models after treatment with 5-FU [203], in rat prostate tumors treated with cyclophosphamide, doxorubicin or paclitaxel [204], in head and neck squamous carcinoma cells treated with docetaxel [205], in neuroblastoma cells treated with valproic acid [206], and in HT-29 colon cancer xenografts treated with metronomic irinotecan [207].