The mechanisms of development of hypertension have not been fully identified, but the following important types of antihypertensive drugs have been widely used: Diuretics (inhibitors of sodium–potassium-chloride co-transporters in the thick ascending limb of Henle’s loop and of sodium-chloride cotransporters in the distal convoluted tubules, and other diuretics), calcium channel blockers, and inhibitors of the renin-angiotensin-system, which include angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor antagonists, and aldosterone receptor antagonists and others. This evidence concerns the gene ACE and Hypertension.