KNG1 and ischemia: Bradykinin is a necessary trigger only during a shorter duration of preconditioning ischemia in pigs [225], or single cycle of ischemia/reperfusion in rabbits [223], but during a more prolonged period (10 min) of preconditioning ischemia [225] or repeated cycles of ischemia/reperfusion [223], the interstitial adenosine concentrations were increased and adenosine is more important.