For NEP, an another renal kininase, BP102 (sinorphan, [(S)-2-[(acetylthio)methyl]-1-oxo-3-pheylpropyl]glycine benzyl ester) [203,204], which was developed as an oral prodrug of NEP inhibitor, thiorphan, largely suppressed the development of hypertension. This evidence concerns the gene MME and hypertensive disorder.