It has also been shown that resveratrol, an activator of sirtuin Sir2 homolog 1 (SIRT1), modulates the SIRT1-PGC-1α pathway having a neuroprotective effect against mutant huntingtin-induced metabolic dysfunction [290] supporting the idea that PGC-1α has an important role in HD. The gene discussed is PPARGC1A; the disease is Huntington disease.