In addition to the defect in mitochondrial complex I, many of the genes involved in PD, such as α-synuclein, parkin, DJ-1, PINK-1 [99,100,101], LRRK-2 [102,103] and HTRA2 [104,105] have also a direct or indirect effect in mitochondria function. This evidence concerns the gene PARK7 and Parkinson disease.