Combined minocycline (an antibiotic with anti-apoptotic and neuroprotective properties) and CoQ10 therapy in a mouse model of HD ameliorated behavioral and neuropathological alterations, reduced gross brain atrophy, striatal neuron atrophy, and huntingtin aggregation, and significantly extended survival and improved motor performance to a greater degree than either minocycline or CoQ10 alone [31]. This evidence concerns the gene HTT and Huntington disease.