LDB1 and squamous cell carcinoma: In addition, widespread LDB1 expression has been demonstrated in embryonic epithelial tissues [38, 39] and at the invasive front of squamous cell carcinoma of the head and neck [40], preventing differentiation of LDB1-overexpressing cells and again suggesting tumor-promoting effects of LDB1. These findings strongly suggest organ-specific effects of Ldb1 and further support our data identifying LDB1 as a negative prognostic factor in CRC.