Our results indicate that in comparison to Dox alone, the combination of lower dose of CFZ and Dox achieved greater inhibitory effect on NB cell proliferation and enhanced PARP and Caspase 3 cleavages in NB cells, suggesting that CFZ is able to efficiently enhance the Dox-induced apoptosis in tumor cells and combination of CFZ and Dox may allow to use lower dose of Dox to achieve a better treatment outcome for NB patients with less Dox-caused side effect. This evidence concerns the gene CASP3 and neoplasm.