Since miR-124-1 played a crucial role in DDX6/c-Myc/PTBI pathway and PTB1/PKM1/PKM2 feedback cascade, down-expression of its target genes PTB1, ROCK1, KITENIN, STAT3 and PRRX1 could inhibit CRC cell proliferation, motility, migration, invasion, tumor growth and enhance radio-sensitivity in vivo and vitro [26, 27, 31–34]. This evidence concerns the gene PKM and neoplasm.