For predicting combined hypercholesterolemia, the values of AUC by sdLDL-C, apoC3, and PCSK9 were 0.919, 95% CI 0.891-0.946; 0.879, 95% CI 0.848-0.911; and 0.606, 95% CI 0.563-0.648; respectively (all p < 0.001). This evidence concerns the gene APOC3 and familial hypercholesterolemia.