For predicting hypercholesterolemia, the values of AUC remained the highest by sdLDL-C (0.726, 95% CI 0.672-0.779, p < 0.001), followed by apoC3 0.674, 95% CI 0.621-0.728, p < 0.001) and PCSK9 (0.609, 95% CI 0.564-0.654, p < 0.001). The gene discussed is PCSK9; the disease is familial hypercholesterolemia.