AKT1 and hepatocellular carcinoma: The uptake of exosomes from invasive HCC cell lines can trigger the activation of phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) and mitogen-activated protein kinase (MAPK) signaling pathways, which resulting in increased secretion of active MMP, enhanced migratory and invasive abilities of non-motile immortalized hepatocytes [24].