High expression of linc-RoR in HCC decreases the expression of miR-145, a linc-RoR target, thereby increasing hypoxia inducible factor-1α (HIF-1α) and pyruvate dehydrogenase kinase isozyme 1 (PDK1) protein expression, overall improving mitochondrial function during hypoxia via the tricarboxylic acid cycle in recipient cells. This evidence concerns the gene PDK1 and hepatocellular carcinoma.