Among these, PVT1 is significantly upregulated in NSCLC tissues and cells, and increased PVT1 expression promotes NSCLC cell proliferation and suppresses apoptosis through epigenetic repression of transcription of the tumor suppressor LATS2 by binding with enhancer of zeste 2 polycomb repressive complex 2 subunit(EZH2) [50]. The gene discussed is EZH2; the disease is non-small cell lung carcinoma.