Cell surface receptors such as human epidermal growth factor 1(HER1), human epidermal growth factor receptor 2 (HER2), and CD20 as well as growth factors such as vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) are used as tumor targets of mAbs; however, these targets are also found in normal cell proliferation and survival and thus are not ideal. Here, ERBB2 is linked to neoplasm.