TP53 and familial pancreatic carcinoma: In addition, we have also demonstrated that GEM sensitivity of p53-null human pancreatic cancer AsPC-1 cells is further enhanced by RUNX2 knockdown through the stimulation of TAp63-dependent cell death pathway [26], which was consistent with the findings that forced expression of TAp73 promotes cell cycle arrest and/or cell death in AsPC-1 cells [27].