Array CGH and exome sequencing of a population of matched pediatric low-grade glioma (PLGG) and secondary high-grade glioma (sHGG) identified BRAFV600E mutation and CDKN2A deletion as the most recurrent alterations in sHGG, at 39% and 57% respectively [8]. The gene discussed is CDKN2A; the disease is glioma.