TRAF3 and neoplasm: The selected DIRP positions are also important for the tumor suppressor interaction regions in Ras recognized by selected antibodies (~35%) and, to a lesser extent, with the Ras Binding Domain (RBD) of different Ras triggered signal effectors (~19%), such as phosphoinositide 3-kinase, Raf, Byr2 or c-Raf1.