Previous reports have shown that FLNa inhibits the inside-out activation of beta1 unless it is displaced by migfilin, as in endothelial cells, or by talin, as in fibroblasts, and that talin1 is required for beta1 activation in PCa cell lines selected to promote bone metastasis in mice [26–28]. This evidence concerns the gene FBLIM1 and posterior cortical atrophy.