Together with PSMA fresh PCa specimens may display a bio-molecular phenotype promoting survival and proliferation owing to a constitutive activation of the PI3K/AKT/mTOR and/or RAF/MEK/ERK pathways, an overexpression of p130CAS (also called BCAR1), a major scaffolding protein of the beta1 integrin (beta1) signalling platform, and an activation of beta1 itself. The gene discussed is BCAR1; the disease is posterior cortical atrophy.