Smoking has been recognized as an independent risk factor for CKD, and smoking might result in intraglomerular hypertension, vascular damage, or glomerulosclerosis via multiple complex interactions of nonhemodynamic (angiotensin II, transforming growth factor-β1, endothelin-1) and hemodynamic factors (Orth and Hallan 2008). The gene discussed is EDN1; the disease is Hypertension.