IGF1 and infection: The presence of systemic inflammation during infection may play a role in growth suppression, as similar linear growth deficits have been noted in other conditions with high levels of systemic inflammation, such as Crohn's disease and juvenile idiopathic arthritis, in which poor growth is associated with high levels of inflammatory markers, low levels of important growth factors such as insulin-like growth factor (IGF)-1, and poor responsiveness of the growth plate [9], [10], [11], [12].