Additionally, we investigated two TCGA cohorts (glioblastoma and brain low-grade glioma) and found that high HSPB1 expression correlated with poor overall survival rate (p = 0.0034 for TCGA glioblastoma multiforme; p = 0.0004 for TCGA Brain Low Grade Glioma) (Fig 5G and 5H). Here, HSPB1 is linked to central nervous system cancer.