The upregulated pathways include Wnt signaling, inflammation mediated by chemokine and cytokine, cholecystokinin signaling map, angiogenesis, interleukin signaling, integrin signaling, platelet-derived growth factor signaling, cadherin signaling while the downregulated pathways include inflammation mediated by chemokine and cytokine, TGF-β signaling, angiogenesis, Huntington disease, Wnt signaling and others (complete list can be found in S6 Table). This evidence concerns the gene CDH17 and juvenile Huntington disease.