IFNA1 and Cirrhosis: For both PIs, whilst the baseline factors of treatment history, cirrhosis status and HCV genotype were not significantly associated with SVR in the present study, it was evident that there was a trend towards higher numbers of IFN-experienced, cirrhotic and HCV genotype 1a individuals in non-SVR groups than in SVR groups, which is in line with clinical trial data [17, 18, 28].