Similarly, the presence of albuminuria and elevated glomerular filtration rate (GFR) were selected as important biomarkers of early renal disease, since they portend further decline in renal function and eventual end-stage renal disease.[10,19] Known genetic variants in APOL1, eNOS and CUBN could influence the onset of renal dysfunction in SCA and contribute to sickle cell nephropathy.[20–22]. The gene discussed is CUBN; the disease is kidney disorder.