CUBN and kidney disorder: AGGF1 is involved in TNF-α induced endothelial activation and has recently been linked with liver fibrosis.[46,47] CYP4B1 is a cytochrome P450 monooxygenase that is expressed in the kidney and recently a long non-coding RNA (lncRNA) of CYP4B1 was associated with nephropathy in diabetic patients.[48] Cubilin has previously been associated with albuminuria; two CUBN variants were tested as candidates but WES analysis identified another CUBN variant (rs111265129, I2189V) protective against renal damage.