PLN and metabolic disease: The top associated network functions included developmental hereditary and metabolic disorders, altered canonical pathways included the LXR/RXR action (p = 7.9E-10), FXR/RXR activation (p = 1.2E-09), acute phase response signaling (p = 2.0E-08), upstream regulators included PLN (p = 4.9E-12), APP (p = 1.45E-08) and microtubule-associated protein Tau (MAPT) (p = 2.5E-09), while molecular and cellular functions included several systems involving 26 molecules in organ morphology, 23 skeletal/muscle and 29 cardiovascular system developments.