The most consistently upregulated genes (p <0.05) in OM-FBS or OM-PL were ALPL, BGN, CLEC3B, COL1A2, DCN and DLX5 after two weeks and BGN, CADM1, CLEC3B, COL1A2, DCN, DLX5 and ELN after one week of OM treatment (Table 3). The gene discussed is COL1A2; the disease is ocular melanoma.