In future study, given the important roles of BAT in obesity and glucose metabolism, the conditional gain-of-function (using Rm155LG transgenic mice[8]) and loss-of-function (using miR-155 floxed mice[53]) of miR-155 in BAT of mice will be employed to fully explore the roles of the miR-155 overexpression-induced decreased BAT mass and function on glucose metabolism (including whole-body insulin sensitivity) in mice. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.