RARA and acute myeloid leukemia: The t(9;11) clone, both in the spleen and the bone marrow (Figures 7b–g), showed a single copy deletion of the Hoxb gene cluster and translocations of both Rara and the oncogene Ets1. Downregulation of either HOXB123 or HOXB924 has been previously observed in a number of human AML cell lines and patient samples; hence, their functional roles in the proper differentiation of the myeloid lineage have been proposed.