APLF and thymus lymphoma: Of note, apart from about 30% of the irradiated Aplf–/–p53–/– and p53–/– mice that died immediately from thymic lymphoma, reminiscent of p53–/– mice (Figure 6b and Supplementary Figure S8B),22 there was no development of thymic lymphoma identified in the necropsies from the rest of the IR-treated wild type, Aplf–/–p53–/–, and p53–/– mice examined.