CNBP and neuroblastoma: Among other alterations, tcof1 knockdown caused a change in cellular nucleic acid-binding protein (cnbp) expression.14Cnbp downregulation had also been reported in mouse neuroblastoma cells with diminished Treacle.16 CNBP, formerly zinc-finger protein 9 (ZNF9), is a single-stranded nucleic acid-binding protein strikingly conserved among vertebrates.17, 18 Mice, chicken and zebrafish embryos deficient in Cnbp display severely affected rostral head structures.19, 20, 21