AKT1 and neoplasm: The downregulation of PCAF in tumor specimens was associated with TNM stage and tumor metastasis and also had negative correlations with survival rate after liver resection.7 Moreover, we found that PCAF increased histone H4 acetylation and inhibited AKT signaling.8 Recently, histone deacetylase inhibitors has been found to induce cell autophagy in HCC cells.9 So we hypothesized a connection between PACF and autophagy in HCC.