Yuan-Ling Liu and others found that two potent HDAC inhibitors induced autophagy in HCC cells through downregulation of Akt/mTOR signaling.9 In addition, increasing numbers of studies revealed that acetyltransferase enzymes also acetylate non-histone proteins, including p53, importin-α adaptor, E1A viral oncoprotein, FOXP3 and Gli1.31, 32, 33, 34, 35, 36 So PCAF may regulate autophagy through acetylating histone protein or other non-histone protein related with autophagy including Key Atg Genes. The gene discussed is MTOR; the disease is hepatocellular carcinoma.