DN is associated with structural changes in the kidney manifested as thickening of the glomerular basement membrane and expansion of the extracellular matrix (ECM) with deposition of collagen type IV and VI, fibronectin and laminin [7], resulting in glomerulosclerosis and tubular interstitial fibrosis, pathological hallmarks of DN. The gene discussed is LAMB2; the disease is liver dysplastic nodule.