Caspase‐3 activation, which is essential for leukemia cell apoptosis, leads to AML1‐ETO oncoprotein cleavage, resulting in the loss of ubiquitination sites and the generation of a 70‐kDa degradable form of AML1‐ETO (ΔAE) 20, 21. The gene discussed is RUNX1; the disease is leukemia.