In the low‐risk DLBCL patients (15 cases), the ZAP70, PI3K, and NFAT mRNA expression levels were 0.64, 0.63, and 0.76 times, respectively, of the healthy controls (P < 0.05, P < 0.05, and P = 0.118, respectively). This evidence concerns the gene ZAP70 and diffuse large B-cell lymphoma.