In the ABC‐type DLBCL patients (19 cases), the ZAP70, PI3K, and NFAT mRNA expression levels were 0.43, 0.48, and 0.57 times, respectively, of the amount in the control group (P < 0.05), while the expression levels in the GCB‐type patients (21 cases) were 0.49, 0.46, and 0.65 times, respectively, of the control group (P < 0.05). The gene discussed is ZAP70; the disease is diffuse large B-cell lymphoma.