RPS6KB1 and cancer: In addition, our previous study showed that H. erinaceus mycelium and extracted erinacine A could be used to investigate in vitro and in vivo antitumour activity through cell cycle arrest in the G1 phase of human DLD‐1 cancer cells involved in the generation of the ROS activates p70S6K, mitogen‐activated protein kinases (MAPK) and NF‐kB pathways, which leads to p21 expression and cdk2/cyclin E and cdk4/cyclin D1 inactivation 12.