In addition, expression levels of β1‐integrin (165 ± 30%), NOX2 (273 ± 27%), and GFAP (150 ± 9%) increased significantly in 18‐month‐old 3xTg‐AD mice compared to age‐matched non‐Tg controls (100%; n = 8 animals in all instances) (Fig 5A,B). The gene discussed is CYBB; the disease is Alzheimer disease.