In order to assess the relevance to AD of dysregulated levels of β1‐integrin and NOX2 in reactive astrocytes, we examined by Western blot, dot blot, and immunohistochemistry assays postmortem samples of prefrontal cortex brain from thirteen control and twenty patients with Alzheimer's disease classified as AD‐II, III, IV and V‐VI (Table 1) (Braak & Braak, 1995). This evidence concerns the gene CYBB and early-onset autosomal dominant Alzheimer disease.