Factors significantly associated with 28-day mortality included low body temperature, low arterial pressure, admission for severe sepsis or septic shock, high INR, high plasma concentrations of creatinine, lactate, and bilirubin, low pH, PaO2/FiO2, platelet count, low albumin, low prothrombin rate, the need of mechanical ventilation, renal replacement therapy, catecholamines, and high levels of all prognostic scores. Here, F2 is linked to Sepsis.