CYSLTR1 and neoplasm: Interestingly, CysLT1 expression increases CRC tumor burden in a gender-specific manner in vivo—In the ApcMin/+ mouse model of familial adenomatous polyposis/sporadic CRC, female mice lacking the CysLT1 gene (Cysltr1−/−ApcMin/+) develop significantly less polyps, less systemic inflammation, and increased regulatory T-cell tumor infiltration, a negative prognostic factor in CRC, compared to Cysltr1+/+ApcMin/+ mice.