CysLT1 signaling activates production of the pro-angiogenic mediator VEGF-A in vitro, while CysLT antagonists modulate vascular permeability and reduce VEGF levels in murine models of allergic asthma and in asthmatic patients (Kanazawa et al., 2004; Lee et al., 2004; Poulin et al., 2011). Here, VEGFA is linked to allergic asthma.