Conversely CysLT2 signaling has been shown to reduce cell migration in MCF-7 breast cancer cell lines, further substantiating many reports that CysLT receptors have opposing effects (Jiang et al., 2007; Magnusson et al., 2007, 2011a; Bengtsson et al., 2013). The gene discussed is CYSLTR2; the disease is breast carcinoma.