Zileuton, a 5-LOX inhibitor, prevents colonic polyp formation in an APCΔ468 mouse model of polyposis and significantly decreases tumor burden in LoVo and HT29 colon cancer murine xenograft models (Melstrom et al., 2008; Gounaris et al., 2015). Here, ALOX5 is linked to malignant colon neoplasm.