During sepsis, various pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS), and endogenous damage-associated molecular patterns (DAMPs), including high mobility group box 1 (HMGB1) and extracellular histones, interact with Toll-like receptors (TLRs) on immune cells and other cells. Here, HMGB1 is linked to Sepsis.