In a study about biomarkers for renal dysfunction in type 2 Diabetes mellitus, U-NAG was the most sensitive marker of microalbuminuria and early renal damage, with sensitivity of 83.3 % compared to serum cystatin C, 2 renal tubular enzymes and neutrophil gelatinase associated lipocalin (NGAL), and β2-microglobulin (β2M) [32] [31]. This evidence concerns the gene B2M and type 2 diabetes mellitus.