INS and hypertriglyceridemia: Hepatic fructose metabolism differs from glucose [35, 38], and, in a hypercaloric setting, fructose induces hypertriglyceridemia and visceral adiposity, promotes lipogenesis and ectopic lipid accumulation, and decreases insulin sensitivity in humans [30, 32, 39–44] as well as rodents [30, 38, 45–52].