Region 5p15.33, showing excess African ancestry associations with ER- breast cancer, contains the TERT gene, which harbors a well-known ER- specific breast cancer associated variant, rs10069690 (Haiman et al., 2011; Garcia-Closas et al., 2013; Michailidou et al., 2013; Purrington et al., 2014). Here, ESR1 is linked to breast cancer.