Incomplete DT-mediated Foxp3+ Treg depletion in naive adult DEREG mice is advantageous to our studies as it enables a window to study effects of Foxp3+ Treg ablation on myelin reactive CD4+ T cells without confounding complications of lymphoproliferative disease and systemic lethal autoimmunity (23, 24). Here, FOXP3 is linked to Autoimmunity.