The significantly up-regulated proteins were mainly infection-associated proteins (such as bifunctional polynucleotide phosphatase/kinase), spore proliferation-related proteins (transcriptional activator, Flap endonuclease 1-A, splicing factor and so on), spore wall proteins (putative SWP9), energy metabolism-related proteins (glyceraldehyde-3-phosphate dehydrogenase 2), proteasome-associated proteins (proteasome subunit alpha type-7, Proteasome component Y13), and so on. Here, PNKP is linked to infection.