Changes in filipin staining were found in NPC fibroblasts transfected with siRNA that targeted low-density lipoprotein receptors (LDLR, APOL1, NPC1, NPC1L1, NPC2, STARD3, STARD4, and RAB9A) and sphingomyelin phosphodiesterase 1, evidencing the role of these genes in lipid metabolism. Here, NPC2 is linked to nasopharyngeal carcinoma.