For example, the rs17197 polymorphism in the 3′-UTR of PTGER2 has been associated with essential hypertension in men (Sato et al., 2007), and the intronic rs2268062 variant in PTGER3 with hypertension in a separate study (Sõber et al., 2009). The gene discussed is PTGER3; the disease is hypertensive disorder.