DLG4 and Stroke: Interestingly, modification of excitatory circuits was recently shown to be also beneficial for preserving plasticity after stroke: OD-plasticity in V1 was preserved after an S1-stroke in mice lacking postsynaptic density protein-95 (Greifzu et al., 2016b), a signaling scaffold protein present at mature excitatory synapses necessary for synaptic maturation (Huang et al., 2015).