Notably, this switch has also been studied in other neurodegenerative diseases, by regulating pivotal genes including MSX3 (Yu et al., 2015), FAM19A3 (Shao et al., 2015) and NF-κB p50 (Taetzsch et al., 2015), or chemical treatments including fasudil (Zhang et al., 2013), malibatol A (Pan et al., 2015), and glatiramer acetate (Burger et al., 2009; Begum-Haque et al., 2013). This evidence concerns the gene NFKB1 and neurodegenerative disease.