BMP2 and colorectal carcinoma: Follow up bioinformatics analysis of CRC gene expression data using the GEO database (GSE21510) revealed similar pattern of down regulation of BMP-2 gene expression in CRC compared to normal tissues, and this was also observed in metastatic and metastatic recurrent CRC lesions, suggesting that loss of BMP2 is an unfavourable event in CRC pathogenesis and progression (Fig. 1b).