TRAF6 and hepatocellular carcinoma: Thus, in order to investigate the relationship between TRAF6 and clinicopathological parameters of HCC, whether TRAF6 plays a role in the proliferation and apoptosis process of HCC or not, we carried out the current study, quantifying the TRAF6 differential expression in liver tissues with continuous pathological states, which could lead to potential development of HCC using immunohistochemistry (IHC) technique, and testing the effects of silencing TRAF6 in HCC HepG2 and Hep3B cell lines with in vitro experiments.